General Medical Drugs Associated with Depression Donald Rogers , PharmD, BCPS and Ronald Pies , MD Psychiatry (Edgmont) . 2008 Dec; 5(12): 28–41. Published online 2008 Dec Given the plethora of drugs implicated in drug induced depression (DID), there is no reason to presume that all drugs produce depression via a common pathophysiological mechanism. And, in as much as the pathophysiology of “ordinary” or idiopathic depression remains uncertain, it would be presumptuous to make confident claims regarding the genesis of DID... Nonetheless, specific depressogenic drugs may induce depression via mechanisms that have been investigated in other contexts. Nonetheless, reduction or depletion of biogenic amines continues to be adduced as one possible mechanism for DID and has by no means been ruled out. 17 Other putative mechanisms 20 , 23 – 25 for DID are listed in Table 1 , but must be considered highly speculative at this time... Finally, the development of DID appears to be mo...
